PUBLICATIONS

REFEREED JOURNALS

Liew, C.Y., Chen, J., Lin, Y., Luo, H., Hung, A., Magoling, B., Nguan, H., Lai, C.P., Ni, C. (2024). Chromatograms and Mass Spectra of High-Mannose and Paucimannose N-Glycans for Rapid Isomeric Identifications. Journal of Proteome Research. 23 (3), 939-955

 

Liew, C.Y., Luo, H., Yang, T., Hung, A., Magoling, B., Lai, C.P., Ni, C. (2023). Identification of the High Mannose N‑Glycan Isomers Undescribed by Conventional Multicellular Eukaryotic Biosynthetic Pathways. Analytical Chemistry. 95(23): 8789-8797.

 

Kao, Y., Chang, Y., Lai, C.P., Chang, N., Huang, C., Chen, C., Huang, H., Juan, H. (2023). Ectopic ATP synthase stimulates the secretion of extracellular vesicles in cancer cells. Communications Biology. 6, 642.

 

Magoling, B., Chen,Y., Wu, A.Y., Wong, W.W., Chou, S.T., Huang, H., Sung, Y., Hsieh, H., Huang, P., Lee, K., Huang, K., Chen,R., Chen,Y., Lai, C.P. (2023). Membrane Protein Modification Modulates Big and Small Extracellular Vesicle Biodistribution and Tumorigenic Potential in Breast Cancers In Vivo. Advanced Materials. 35(13): e2208966.

 

Chen, Y., Chen, C., Lai, C.P., Lee, G. (2022). Isolation and digital counting of extracellular vesicles from blood via membrane-integrated microfluidics. Sensors and Actuators B: Chemical. 358:131473.

 

Verweij., F., Balaj, L., Boulanger, C., Carter, D., Compeer, E., D’Angelo, G., El Andaloussi, S, Goetz, J.G., Gross, J., Hyenne, V., Krämer-Albers, E., Lai, C.P., Loyer, X., Mark, A., Momma, S., Hoen, E., N., Pegtel, M., Peinado, H., Raposo, G., Rilla, K., Tahara, H., Théry, C., van , M., Vandenbroucke, R., Wehman, A., Witer, K., Wu, Z., Wubbolts, R., Niel, G.V. (2021). The power of imaging to understand extracellular vesicles in vivo. Nature Methods. 18 (9): 1013-1026.

 

Chien, J.C., Badr, C.E.*, Lai, C.P.* (2021). Multiplexed bioluminescence-mediated tracking of DNA double strand break repairs in vitro and in vivo. Nature Protocols. 16, 3933-3953. *Co-last authors.

 

Gimona, M., Brizzi, M.F., Choo, A.B.H., Dominici, M., Davidson, S.M., Grillari, J., Hermann, D.M., Hill, A.F., Kleijn, D., Lai, R.C., Lai, C.P., Lim, R., Monguió-Tortajada, M., Muraca, M., Ochiya, T., Ortiz, L.A., Toh, W.S., Yi, Y.W., Witwer, K.W., Giebel, B., Lim, S.K. (2021). Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles. Cytotherapy. 23 (5): 373-380.

 

Chen, Y., Lai, C.P., Chen, C., Lee, G. (2021). Isolation and recovery of extracellular vesicles using optically-induced dielectrophoresis on an integrated microfluidic platform. Lab on a Chip. 21 (8): 1475-1483.

 

Wu, A.Y., Sung, Y., Chen, Y., Chou, S.T., Guo, V., Chien, J.C., Ko, J.J., Yang, A.L., Huang, H., Chuang, J., Wu, S., Ho, M., Ericsson, M., Lin, W., Cheung, C.H.Y., Juan, H., Ueda, K., Chen, Y., Lai, C.P. (2020). Multiresolution imaging using bioluminescence resonance energy transfer identifies distinct biodistribution profiles of extracellular vesicles and exomeres with redirected tropism. Advanced Science. 7 (19): 2001467-83.

 

Chien, J.C., Tabet, E., Pinkham, K., da Hora, C.C., Chang, J.C., Lin, S., Badr, C.E.*, Lai, C.P.* (2020). A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo. Nucleic Acids Research. 48 (17): e100-117. *Co-last authors.

 

Maas, S.L.N., Abels, E.R., Van De Haar, L.L., Zhang, X., Morsett L., Sil, S., Guedes, J., Sen, P., Prabhakar, S., Hickman, S.E., Lai, C.P., Ting, D.T., Breakefield, X.O., Broekman, M.L.D., El Khoury, J. (2020). Glioblastoma hijacks microglial gene expression to support tumor growth. Journal of Neuroinflammation. 17(1): 120.

 

Huang, Y., Fan, C., Hsu, N., Chiu, N., Wu, C., Chang, C., Wu, B., Hong, S., Chang, Y., Wu, A.Y., Guo, V., C, Y., Hsu, W., C, L., Lai, C.P., Yeh, C., Lin, Y. (2019). Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein. Nano Letters. 20 (2): 1089-1100.

 

Sung, Y., Jin, P., Chu, L., Hsu, F., Wang, M., Chang, C., Chiou, S., Qiu, J.T., Gao, D., Lin, C., Chen, Y., Hsu, Y., Wang, J., Wang, F., Yu, P., Chiang, A., Wu, A.Y., Ko, J.J., Lai, C.P., Lu, T.*, Chen, Y.* (2019). Delivery of nitric oxide with a nanocarrier promotes tumor vessel normalization and potentiates anti-cancer therapies. Nature Nanotechnology. 2 (13):266-10. *Co-last authors.

 

Zaborowski, M.P., Lee, K., Na, Y.J., Sammarco, A., Zhang, X., Iwanicki, M., Cheah, P.S., Lin, H.Y., Zinter, M., Chou, C., Fulci, G., Tannous, B.A., Lai, C.P., Birrer, M.J., Weissleder, R., Lee, H., Breakefield, X.O. (2019). Methods for systematic identification of membrane proteins for specific capture of cancer-derived extracellular vesicles. Cell Reports. 27 (1):255-268.e6.

 

Wu, Y.T., Ueda, K., Lai, C.P. (2019). Proteomic analysis of extracellular vesicles for cancer diagnostics. Proteomics. 19 (1-2): 1800162-27.

 

Chuo S.T.*, Chien, J.C.*, Lai, C.P. (2018). Imaging extracellular vesicles: current and emerging methods. Journal of Biomedical Science. 25:91-100. *Co-first authors.

 

Reátegui E.*, van der Vos K.E.*, Lai, C.P.*, Zeinali M., Atai N.A., Aldikacti B., FloydJr, F.P., Khankhel, A.H., Thapar, V., Hochberg, F.H., Sequist, L.V., Nahed, B.V., Carter, B.S., Toner, M., Balaj, L., Ting, D.T., Breakefield, X.O., Stott, S.L. (2018). Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Nature Communications. 9 (1): 175-186. *Co-first authors.

 

Sung, Y., Liu, Y., Chao, P., Chang, C., Jin, P., Lin, T., Lin, J., Cheng, H., Wang, J., Lai, C.P., Chen, L., Wu, A.Y., Ho, T., Chiang, T., Gao, D., Duda, D.G., Chen, Y. (2018). Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development. Theranostics, 8 (4): 894-905.

 

Reiner, A.T., Witwer, K.W., van Balkom, B.W.M., de Beer, J., Brodie, C., Corteling, R.L., Gabrielsson, S., Gimona, M., Ibrahim, A.G., de Kleijn, D., Lai, C.P., Lötvall, J., Del Portillo, H.A., Reischl, I.G., Riazifar, M., Salomon, C., Tahara, H., Toh, W.S., Wauben, M.H.M., Yang, V.K., Yang, Y., Yeo, R.W.Y., Yin, H., Giebel, B., Rohde, E., Lim, S.K. (2017). Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles. Stem Cells Translational Medicine, 6 (8): 1730-1739.

 

Mateescu, B., Kowal, E.J., van Balkom, B.W., Bartel, S, Bhattacharyya S.N., Buzás, E.I., Buck, A.H., de Candia, P., Chow, F.W., Das, S., Driedonks, T.A., Fernández-Messina, L., Haderk, F., Hill, A.F., Jones, J.C., Van Keuren-Jensen, K.R., Lai, C.P., Lässer, C., Liegro, I.D., Lunavat, T.R., Lorenowicz, M.J., Maas, S.L., Mäger, I., Mittelbrunn, M., Momma S., Mukherjee, K., Nawaz, M., Pegtel, D.M., Pfaffl, M.W., Schiffelers, R.M., Tahara, H., Théry, C., Tosar, J.P., Wauben, M.H., Witwer, K.W., Nolte-'t Hoen, E.N. (2017). Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper. Journal of Extracellular Vesicles, 6 (1): 1286095.

 

Pucci, F., Garris, C., Lai, C.P., Newton, A., Pfirschke, C., Engblom, C., Alvarez, D., Sprachman, M., Evavold, C., Magnuson, A., von Andrian, U.H., Glatz, K., Breakefield, X.O., Mempel, T.R., Weissleder, R., Pittet, M.J. (2016). SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science, 352 (6282): 242-246.

 

Hall, J., Prabhakar, S., Balaj, L., Lai, C.P., Cerione, R.A., Breakefield, X.O., (2016). Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson’s Disease, Glioma, and Schwannoma. Cellular and Molecular Neurobiology, 36 (3): 417-427.

 

van der Vos, K.E.*, Abels, E.R.*, Zhang, X.*, Lai, C.P., Carrizosa, E., Oakley, Dl., Prabhakar, S., Mardini, O., Crommentuijn, MH., Skog, J., Krichevsky, A.M., Stemmer-Rachamimov, A., Mempel, T.R., El Khoury, J., Hickman, S.E, Breakefield, X.O. (2016). Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain. Neuro-oncology, 82 (1): 58-69. *, Co-first authors.

 

Lai, C.P., Kim, E.Y., Badr, C.E., Weissleder R., Mempel, T.R., Tannous, B.A., Breakefield, X.O. (2015). Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters. Nature Communications, 6: 7029.

 

Zaborowski, M.P., Balai, L., Breakefield, X.O., Lai, C.P. (2015). Extracellular vesicles: composition, biological relevance and methods of study. Bioscience, 65 (8): 783-797.

 

Prabhakar S., Zhang X., Goto J., Han S., Lai C.P., Bronson R., Sena-Esteves M., Ramesh V., Stemmer-Rachamimov A., Kwiatkowski D.J., Breakefield, X.O. (2015). Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model. Neurobiology of Disease, 82: 22-31.

 

Lai, C.P., Mardini, O., Ericsson, M., Prabhaker, S., Maguire A., Chen, J.W., Tannous, B.A., Breakefield, X.O. (2014). Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter. ACS Nano, 8 (1): 483-494.

 

Laurent, L.C., Abdel-Mageed, A.B., Adelson, P.D., Arango, J., Balaj, L., Breakefield, X., Carlson, E., Carter, B.S., Majem, B., Chen, C.C., Cocucci, E., Danielson, K., Courtright, A., Das, S., Abd Elmageed, Z.Y., Enderle, D., Ezrin, A., Ferrer, M., Freedman, J., Galas, D., Gandhi, R., Huentelman, M.J., Van Keuren-Jensen, K., Kalani, Y., Kim, Y., Krichevsky, A.M., Lai, C.P., Lal-Nag, M., Laurent, C.D., Leonardo, T., Li, F., Malenica, I., Mondal, D., Nejad, P., Patel, T., Raffai, R.L., Rubio, R., Skog, J., Spetzler, R., Sun, J., Tanriverdi, K., Vickers, K., Wang, L., Wang, Y., Wei, Z., Weiner, H.L., Wong, D., Yan, I.K., Yeri, A., Gould, S. (2015). Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. Journal of Extracellular Vesicles, 4:26533.

 

Patton, J.G., Franklin, J.L., Weaver, A.M., Vickers, K., Zhang, B., Coffey, R.J., Ansel, K.M., Blelloch, R., Goga, A., Huang, B., L'Etoille, N., Raffai, R.L., Lai, C.P., Krichevsky, A.M., Mateescu, B., Greiner, V.J., Hunter, C., Voinnet, O., McManus, M.T. (2015). Biogenesis, delivery, and function of extracellular RNA. Journal of Extracellular Vesicles, 4:27494.

 

Wang, N., De Vuyst, E., Ponsaerts, R., Boengler, K, Palacios-Prado, N., Wauman, J., Lai, C.P., De Bock, M., Decrock, E., Bol, M., Vinken, M., Rogiers, V., Tavernier, J., Evans, W.H., Naus, C.C., Bukauskas, F.F., Sipido, K.R., Heusch, G., Schulz, R., Bultynck, G., Leybaert, L. (2013). Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Research in Cardiology, 108 (1):309.

 

Lai, C.P., Breakefield, X.O., (2012). Role of exosomes/microvesicles in the nervous system and use in emerging therapies. Frontiers in Physiology, 3: 228.

 

Bao, B., Lai, C.P., Naus, C., Morgan, J.R. (2012). Pannexin1 drives multicellular aggregate compaction via a signaling cascade that remodels the actin cytoskeleton. Journal of Biological Chemistry, 287 (11): 8407-8416.

 

Lai, C.P., Bechberger, J., Naus, C. (2009). Pannexin2 as a Novel Growth Regulator in C6 Glioma Cells. Oncogene, 28 (49): 4402-4408.

 

Elke De Vuyst, Nan Wang, Elke Decrock, Marijke De Bock, Mathieu Vinken, Marijke Van Moorhem, Charles Lai, Maxime Culot, Vera Rogiers, Romeo Cecchelli, Christian C. Naus, W. Howard Evans, Luc Leybaert. (2009). Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells. Cell Calcium, 46 (3): 176-187.

 

Decrock, E., De Vuyst, E., Vinken, M., Van Moorhem, M., Vranckx, K., Wang, N., Van Laeken, L., De Bock, M., D’Herde, K., Lai, C.P., Rogiers, V., Evans, W.H., Naus, C., Leybaert, L. (2008). Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model. Cell Death & Differentiation, 16 (1): 151-163.

 

Lai, C.P., Bechberger, J., Thompson, R.J., MacVicar, B., Bruzzone, R., Naus, C. (2007). Tumor-suppressive Effects of Pannexin 1 in C6 Glioma cell. Cancer Research, 67 (4): 1545-1554.

 

Kozoriz, M.G., Bates, D.C., Bond, S.R., Lai, C.P., Moniz, D.M. (2006). Passing potassium with and without gap junctions. Journal of Neuroscience, 26 (31): 8023-8024.

 

 

BOOK CHAPTERS

 

Wu, A.Y., Lai, C.P. (2017). Tracking Extracellular Vesicles Delivery and RNA Translation Using Multiplexed Reporters. Methods in Molecular Biology, 1660: 255-265.

 

Lai, C.P., Tannous, B.A., Breakefield, X.O. (2014). Noninvasive in vivo monitoring of extracellular vesicles. Bioluminescent Imaging: Methods and Protocols, 249-258.

 

Lai, C.P., and Naus, C. (2009). Connexins and pannexins: Two gap junction families mediating glioma growth control. Astrocytes in (patho)physiology of the nervous system, 547-567.

 

Lai, C.P., Bechberger, J., Naus, C. (2009). Pannexins. Encyclopedia of Cancer, 2257-2259.