We create and apply new technologies to explore biological phenomena!
ABOUT OUR LAB
Welcome to the Lai Lab at Academia Sinica, Taiwan. Our research focuses on molecular bioimaging, cell-to-cell communication and gene therapy.
Extracellular vesicles (EVs) including exosomes and microvesicles are nanometer-sized particles released by cells to transfer proteins, nucleic acids and lipids to communicate locally and distally. By contrast, abnormal cells exploit EVs as a means to guide normal cells for disease propagation. While the (patho)physiological functions of EVs have been reported, it remains unclear as to how cells employ them as a communication network. Our lab combines expertise on imaging and genetic engineering to develop novel imaging technologies to further our understanding and application of EV-based cell-to-cell communications.
Investigating DNA repair dynamics is another main research arm of Lai Lab. Eukaryotic cells constantly repair DNA to maintain their genome integrity and cell viability. In fact, DNA repair dynamic plays a key role in the efficacy of cancer and gene therapies. However, studying DNA repair in vivo is challenging where conventional methods typically require disruption of cells/animals. Our research focuses on developing non-disruptive and highly sensitive methods to track DNA repair dynamics and enhance cancer and genome therapy developments.
Congratulations to Bryan John Magoling (孟古寧) on winning 1st Place at 2023 Falling Walls Lab Tokyo!
Congratulations to Steven Ting-Yu Chuo (卓庭煜) on receiving the Young Researcher Scholarship from the 2023 International Society for Extracellular Vesicle (ISEV) annual meeting!
Congratulations to Bryan John Magoling (孟古寧) on winning the Excellent Poster Award in the 2023 Chemistry National Meeting!
Bryan John Magoling's (孟古寧) latest research on big and small EVs is now published in Advanced Materials!
Congratulations to Bryan John Magoling (孟古寧) on receiving 2022 IAMS Young Fellow Outstanding Oral Presentation Award!
Congratulations to Steven Ting-Yu Chuo (卓庭煜) on receiving 2022 IAMS Young Fellow Outstanding Oral Presentation Award!
Congratulations to Anthony Yan-Tang Wu (吳晏瑭) on receiving 2022 IAMS Young Fellow Poster Award!
Congratulations to Sophie Shin Lu (盧欣) on receiving 2022 IAMS Young Fellow Poster Award!
Congratulations to Rachel Hei-Yu Lam (林熙如) on winning the 2022 IAMS Summer Research Internship Presentation Award!
Congratulations to Bryan John Magoling (孟古寧) on receiving 2022 Joint IAMS-NTNU-YCU Workshop Most Outstanding Oral Presentation Award!
Institute of Atomic and Molecular Sciences, Academia Sinica
No. 1, Roosevelt Rd., Sec. 4, Taipei, 10617, Taiwan